kinin
IPA: kˈɪnɪn
noun
- (biochemistry) Any of various structurally related polypeptides of the autacoid family, such as bradykinin and kallikrein, that act locally to induce vasodilation and contraction of smooth muscle.
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Examples of "kinin" in Sentences
- He enjoyed the kinin 'a mite too much for my comfort.
- "Then that John, he murmured," That old bitch is kinin 'all the little mice in the attic.
- They reported that in endothelial cells, kinin B1 receptors activate iNOS via ERK-mediated phosphorylation of its Ser
- However, little is known about the regulatory effects of kinin receptors on the onset of acute inflammation and inflammatory pain in humans.
- The present study was designed to examine if nicotine could induce airway hyperresponsiveness through kinin receptors, and if so, explore the underlying mechanisms involved.
- The enhanced contractile responses were accompanied by increased mRNA and protein expression for both kinin receptors, suggesting the involvement of transcriptional mechanisms.
- Kinins play an important role in regulation of pain and hyperalgesia after tissue injury and inflammation by activating two types of G-protein-coupled receptors, the kinin B1 and B2 receptors.
- These results provide evidence at the transcriptional level in a clinical model of tissue injury that up-regulation of kinin receptors are involved in the development of the early phase of inflammation and inflammatory pain.
- It is in the autonomic system, is related to the signals coming into the dorsal horn, but has an additional pathway that can trigger local prostaglandin (at least) release independent of inflammatory substances separate from local kinin-kallikrein.
- The present study investigated the changes in gene expression of kinin receptors and the levels of their endogenous ligands at an early time point following tissue injury and their relation to clinical pain, as well as the effect of COX-inhibition on their expression levels.
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