megakaryocyte

IPA: mˈɛgʌkˈɑrˈaɪʌsaɪt

(anatomy) A large cell, found in bone marrow, responsible for the production of platelets.

Examples of "megakaryocyte" in Sentences

The cytoplasm of the megakaryocyte fragments at the edge of the cell.
Platelets are formed in the cytoplasm of a very large cell, the megakaryocyte.
Lagrue-Lak-Hal AH, Debili N, Kingbury G, Lecut C, Le Couedic JP, et al. (2001) Expression and function of the collagen receptor GPVI during megakaryocyte maturation.
Boer AK, Los EL, Esselink MT, Vellenga E (2005) Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase.
"Our study indicates that the dysregulation of PLAU in Quebec platelet disorder extends beyond megakaryocyte lineage, to involve other cells of the myeloid lineage," the investigator said.
The condition also is characterized by proteolysis of platelet α-proteins such as platelet factor V and von Willebrand factor, further interfering with clot function, and with increased uPA messenger RNA levels, particularly during megakaryocyte differentiation.