aggravation

"The constant noise from the construction site was causing great aggravation."

"His late arrival was an aggravation that could have been avoided."

"She felt a sense of aggravation when her plans kept getting interrupted."

"The poor handling of the situation only served to aggravate tensions between the teams."

"Don't aggravate your injury by trying to play sports too soon."

"His comments on the issue may aggravate the already heated debate."