breakthrough

IPA: brˈeɪkθru

(military) An advance through and past enemy lines.
Any major progress; such as a great innovation or discovery that overcomes a significant obstacle.
(sports) The penetration of the opposition's defence.
(construction) The penetration of a separating wall or the remaining distance to an adjacent hollow (a crosscut in mining) or between two parts of a tunnel build from both ends; knockthrough.

Characterized by major progress or overcoming some obstacle.
(immunology) Involving the contraction of a disease by a person with a decreased susceptibility, such as a person who has been vaccinated to help prevent that disease.
(medicine) The emergence or one or more symptoms of a condition despite medication or other medical treatment.

Examples of "breakthrough" in Sentences

The scientist made a groundbreaking breakthrough in cancer research with a new treatment method
The artist experienced a creative breakthrough after months of feeling stuck
The athlete's performance improved drastically after she made a breakthrough in her training regimen
The company's new technology was hailed as a breakthrough in the industry
The student had a breakthrough in understanding a difficult concept after receiving extra help from a tutor