ligand
IPA: ɫˈɪgʌnd
noun
- (chemistry) A molecule or moiety (ion, functional group, or radical) that binds to another chemical entity to form a larger complex; as, especially:
- (coordination chemistry) Such an entity that binds to a central metal atom to form a coordination complex.
- (biochemistry, physiology, pharmacology, medicine) Such an entity that forms a complex with a biomolecule to serve a biological purpose.
- (typography) A letter that orthography requires or allows to be ligated with one or more other letters to form a ligature, such as a in æ or o in œ.
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Examples of "ligand" in Sentences
- Cyclooctatetraenide as a ligand.
- Cell signaling and ligand binding.
- The acetate ligands are not bidentate.
- Cymene is a common ligand for ruthenium.
- Desensitization and ligand concentration.
- The position isomer of ligand gives ligand isomerism.
- The ligands employed are labile and are weakly coordinating.
- On binding a ligand the protein and ligand are internalized.
- The ligand may be an antigen and the receptor, the antibody to the antigen.
- In fact one of the most potent ligands, xorphanol, was the least efficacious.
- It turns out that a single molybdenum center within a properly designed protective ligand is sufficient.
- This first-in-class monoclonal antibody targets RANK ligand, which is involved in bone-degenerating osteoclasts.
- Recently the intracellular protein BAT3, which is involved in DNA damage induced apoptosis, was identified as a ligand for NKp30.
- He introduced the system of 'Stock notation' in 1919 for naming inorganic compounds containing elements with variable valencies (for example copper (I) sulphate and copper (II) sulphate) and introduced the word 'ligand' in transition metal chemistry.
- (A ligand is a molecule that binds to the receptor to form a biologically active complex.) "In bad times, the ligand is not made and the nuclear receptor (DAF-12) causes the animals to go into the long lived dauer stage, shutting down the microRNAs and the developmental clock," he said.
- KemPharm's LAT platform generates modified versions of FDA-approved drugs by chemically attaching a removable substituent, called a ligand, to the approved drug, resulting in a prodrug that is an NCE with potentially improved therapeutic characteristics based on enhanced pharmacokinetic profiles and other characteristics.
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