verb

• (transitive) To move, arrange or operate something using the hands
• (transitive) To influence, manage, direct, control or tamper with something
• (transitive, medicine) To handle and move a body part, either as an examination or for a therapeutic purpose
• (transitive) To influence or control someone in order to achieve a specific purpose, especially one that is unknown to the one being manipulated and beneficial to the manipulator; to use
• (intransitive, dated) To use the hands, especially in scientific experiments.