oestrone
IPA: ˈoʊstrˈoʊni
noun
- (British spelling, biochemistry, steroids) Alternative spelling of estrone. [(American spelling, biochemistry, steroids, pharmacology) A natural estrogenic hormone that is a ketone C₁₈H₂₂O₂ found in the body chiefly as a metabolite of and less potent than estradiol, that is also secreted especially by the ovaries, and that is used to treat various conditions (such as ovarian failure and menopausal symptoms) relating to estrogen deficiency.]
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Examples of "oestrone" in Sentences
- He isolated and identified conjugated oestrone sulphate Premarin .
- In 1929 he isolated oestrone in pure, crystalline form, almost at the same time that
- Butenandt named this substance folliculine, a designation which was later changed to oestrone.
- It differs from oestrone only in the additional content of 1 methyl group and 5 hydrogen atoms.
- Butenandt confirmed Marrian's discovery and explained the relationship between the new substance and oestrone.
- In 1929-1930 he succeeded in isolating oestrone, a feat independently accomplished at about the same time by Butenandt in
- Shortly after the discovery of oestrone, Marrian in London (1930) isolated from the urine of pregnant women a new hormone which he called oestriol.
- In the process of purification it proved that the male hormone behaved in many respects like oestrone; when he realized this, it made Butenandt's work considerably easier.
- From about the 40th day of pregnancy, the foetal-placental unit of pregnant mares start to produce increasing amounts of oestrone sulphate, which enters the mare's blood and urine.
- In 1932, Butenandt was able, from observations made in spectral analysis, and especially on the basis of the then established correct formula of cholesterol to draw up the formulae of the chemical structure of oestrone and oestriol.
- The two chemical hormones commonly measured to provide information on the pregnancy status of miniature mares are pregnant mare serum gonadotrophin (PMSG), which is frequently now called chorionic gonadotrophin (eCG), and oestrone sulphate (see main story for more information).