proteosome

IPA: prˈoʊtiʌsoʊm

Alternative spelling of proteasome [(biochemistry) A complex protein, found in bacterial, archeal and eukaryotic cells, that breaks down other proteins via proteolysis.]

Examples of "proteosome" in Sentences

The degradation may be mediated possibly via the proteosome or calpain.
The alpha synuclein ubiquitin complex cannot be directed to the proteosome.
Proteolysis is highly processive, and the protein is degraded by the proteosome.
The cell has its own trash can called the proteosome, and damaged proteins are deposited there.
The researchers wanted to see if they could find a molecule that inhibited Usp14, thus allowing the proteosome to work effectively.
Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.
Brunelle et al. found that the different cytotoxic drugs all caused a rapid decrease in MCL-1 protein levels via proteosome-mediated degradation, allowing cell death to proceed quickly.
Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, et al. (2002) Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
Advancement of therapeutics is unfortunately too frequently driven by serendipity; Takeda/Millennium's own successful drug Velcade (bortezomib), a first-in-class proteosome inhibitor, is one example.
In particular, they found that drugs called proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into their proper protein form.