tobramycin
IPA: tˈoʊbræmˈaɪsɪn
noun
- (pharmacology) A colorless water-soluble aminoglycoside antibiotic C₁₈H₃₇N₅O₉, isolated from a soil bacterium Streptoalloteichus tenebrarius and used especially against Gram-negative bacteria. When used in combination with loteprednol to treat inflammatory conditions of the eye, tobramycin is marketed under the trademark Zylet.
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Examples of "tobramycin" in Sentences
- Tobramycin may be administered in a nebulized form.
- Various formulae exist for calculating tobramycin dosage.
- He is halfway through his course of tobramycin, and bored to death.
- Therapeutic potential disruption brought tobradex review before tobramycin achieve.
- Over the years they came up with a string of alternatives, including neomycin, kanamycin, gentamicin and tobramycin.
- The drug, tobramycin or TOBI, joined the Novartis portfolio as part of its 2005 takeover of biotechnology firm Chiron Corp.
- Antibiotics like ciprofloxacin and tobramycin kill bacteria partly by inducing the overproduction of free radicals and causing oxidative stress.
- GL, Liu W, Fregeau C, Kulawy R, Louie A (2009) Differing effects of combination chemotherapy with meropenem and tobramycin on cell kill and suppression of resistance of wild-type
- "We learned that simply by adapting to the conditions inside the airways of cystic fibrosis patients, mutated Pseudomonas can withstand the effects of ciprofloxacin and tobramycin,"
- TOBI Podhaler tobramycin inhalation powder was approved in the EU as a suppressive therapy for chronic Pseudomonas aeruginosa lung infections in patients with cystic fibrosis aged six years and older .
- TOBI Podhaler is a new dry powder formulation of the antibiotic tobramycin, delivered using a more convenient, patient-friendly device that reduces administration time by 72% relative to TOBI nebulizer solution, with comparable efficacy.
- Because lasR mutant Pseudomonas has been associated with worse outcomes in cystic fibrosis patients, indentifying Pseudomonas with the lasR mutation may be of prognostic value and may indicate the need for treatment with specific antibiotics like monobactams, tetracyclines, or polymyxin, whose mode of action differs from ciprofloxacin and tobramycin.