zymogen
IPA: zˈaɪmʌgʌn
noun
- (biochemistry) A proenzyme, or enzyme precursor, which requires a biochemical change (i.e. hydrolysis) to become an active form of the enzyme.
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Examples of "zymogen" in Sentences
- In such a model, cells secrete MMP-2 as an inactive zymogen (Pro-MMP-2) containing 8 disulphide bonds
- Vande Haar penned a 12-verse epic in which he manages to rhyme words like "phospholipids," "hemorrhage" and "zymogen."
- This prodomain maintained MMP-2 as a zymogen and this loop is cleaved by MMP-14 after MMP-2 secretion given active form.
- The loss of vacuole acidification in V-ATPase mutants prevents zymogen activation and causes defects in the proteolytic function of the vacuole
- Trypsin itself then cleaves lysine peptide bonds, and so, once a small amount of trypsin is generated, it participates in cleavage of its own zymogen, generating – more trypsin!
- Protein C is a serine protease blood coagulation factor that circulates as an inactive zymogen and is activated by thrombin during blood coagulation to form activated protein C APC.
- This enzyme contains an amino-terminal signal sequence (Pre) that directs it to the secretory pathway via the endoplasmic reticulum (ER) and a propeptide (Pro) that maintains it as inactive zymogen
- Redman, David Sabatini and Yutaka Tashiro; it led to the characterization of the zymogen granules and to the discovery of the segregation of secretory products in the cisternal space of the endoplasmic reticulum.
- As of this typing, it contains 13 scrolling screens of active netlabels (OK, I'm on a netbook; your scrolling may vary), from the Guadalajara, México-based zymogen.net (plus a bunch whose monikers start with numbers or symbols).
- It may very likely produce the same change in the membrane that is caused by the entrance of the spermatozoon under normal circumstances -- membrane formation may be necessarily coincident with the liberation in the egg of some zymose which arises from a pre-existent zymogen.
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